Predictive tools, like models, can be used to predict the changes required in a cell to produce a given bioproduct. The modeling technologies are still in their infancy but are becoming more accurate thanks to the research that has been done in the last decade.
New developments in modeling technology allow members of the USTAR-funded Synthetic Bioproducts Center at USU to accurately predict improved synthetic biological processes that can be used to manufacture products—including biliverdin, bioplastics and spider silk proteins.
Using these mathematical models of cells, SBC team members can determine which metabolic pathways need to be changed or modified to optimize the cell to maximize the production of a given bioproduct—a necessary step in scaling up the biomanufacturing process.
|Efficient Systems for Monitoring and Recovering Polyhydroxyalkanoates (Poster)||Elisabeth Linton, Trent Mortensen, Ronald C. Sims, H. Scott Hinton, and Charles D. Miller||Institute of Biological Engineering 2009 Annual Conference||2009|
|Design of a gene expressions system for Rhodobacter sphaeroides||J. Huo, R. C. Sims, and H. S. Hinton||Institute of Biological Engineering 2010 Annual Conference||2010|
|CyanoBricks: Genomic Engineering Tools for the Photosynthetic Cyanobacterium Synechocystis||Charles D. Miller, Cody Tramp, Alex Hatch, Cole Peterson, Brad Henrie, Shujie Shen, Abiezer Tejeda, Eduardo Monzon, H. Scott Hinton, and Ronald Sims||Institute of Biological Engineering 2011 Annual Conference||2011|
|Designing predictive mathematical models for the metabolic pathways associated with polyhydroxybutyrate synthesis in Escherichia coli||Angela Dixon, Ronald C. Sims, Charles D. Miller, and H. Scott Hinton||Institute of Biological Engineering 17th Annual Conference||2012|
|Pathway Pioneer: A Network Visualization and Flux Analysis Tool||Nicholas S. Flann, Jonathan Valiente, Misty Wallace, Richard Brown, Scott Hinton||Annual Conference of the Institute for Biological Engineering||2013|
|Pathway Pioneer: A web-based metabolic network layout tool for comprehensive visualization of complex networks||Harsh Dosi, Sumit Kumar Singh, Nicholas S. Flann, H. Scott. Hinton||2014 IBE Annual Meeting||2014|
|Pathway Pioneer: a tool for metabolic network visualization and flux analysis (Poster)||Sumit Kumar Singh, Harsh Dosi, Vipul Oswal, Nicholas S. Flann; H. Scott. Hinton||2014 IBE Annual Meeting||2014|