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Functional dissection and module swapping of fungal cyclooligomer depsipeptide synthetases

Abstract:

BbBSLS and BbBEAS were dissected and reconstituted in Saccharomyces cerevisiae. The intermodular linker is essential for the reconstitution of the separate modules. Module 1 can be swapped between BbBEAS and BbBSLS, while modules 2 and 3 control the product profiles. BbBSLS is a flexible enzyme that also synthesizes beauvericins.

Author:

Yu, D., Xu, F., Gage, D., Zhan, J.*

Journal:

Chemical Communications

Citation:

Yu, D., Xu, F., Gage, D., Zhan, J.* (2013): Functional dissection and module swapping of fungal cyclooligomer depsipeptide synthetases. Chemical Communications 49, 6176-6178.

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